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Literature summary for 3.1.4.1 extracted from
- Characterization of phosphodiesterase 1 in human malignant melanoma cell lines (2009), Anticancer Res., 29, 1119-1122.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| full open reading frames for PDE1C1 and PDE1C3 are cloned | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| vinpocetin | 10 mU, surpresses the increase of activity, caused by the addition of 0.2 mM Ca2+ | Homo sapiens |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 0.2 mM activity in MAA cells stimulated ca. 2fold, with calmodulin | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| melanoma cell line | human malignant melanoma MAA cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cAMP + H2O | incubated with or without 0.2 mM CaCl2, 10 mU calmodulin, and PDE1 inhibitor vinpocetin, 30°C, pH 7.5 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE1 | - |
Homo sapiens |
| phosphodiesterase 1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | PDE1 mRNA expression is investigated | additional information |
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