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Literature summary for 3.1.4.1 extracted from

  • Li, Y.; Liu, J.; Hudson, M.; Kim, S.; Hatch, N.E.
    FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling (2010), J. Cell. Biochem., 111, 1346-1358.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
both Msx2 and Runx2 are recruited to a conserved core Msx2 binding site within the PC-1 gene promoter upon FGF2 stimulation, promoter analysis, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutation of the Msx2 DNA binding site, to prevent binding of Msx2 to this site, inhibits PC-1 promoter activity in FGF2 treated MC3T3E1(C4) calvarial pre-osteoblast cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoblast
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PC-1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens fibroblast growth factor-2, FGF2, specifically induces PC-1 expression in calvarial pre-osteoblasts, which occurs via a transcriptional mechanism involving Runx2. FGF2 promotes Msx2-stimulated PC-1 expression via Frs2/MAPK signaling, Msx2 promotes transcription of the PC-1 gene downstream of FGF2, overview. both Msx2 and Runx2 are recruited to a conserved core Msx2 binding site within the PC-1 gene promoter upon FGF2 stimulation, and that Msx2 and Runx2 function together to induce PC-1 gene expression in osteoblastic cells up

General Information

General Information Comment Organism
physiological function PC-1 is an enzymatic generator of diphosphate and a critical regulator of tissue mineralization Homo sapiens