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Literature summary for 3.1.4.1 extracted from

  • Asensio, A.C.; Rodriguez-Ferrer, C.R.; Castaneyra-Perdomo, A.; Oaknin, S.; Rotllan, P.
    Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system (2007), Neurochem. Int., 50, 581-590.
    View publication on PubMed
Search for more literature for 3.1.4.1

Activating Compound

Activating Compound Comment Organism Structure
Ca2+ maximal effect around 2 mM Rattus norvegicus
Mg2+ maximal effect around 2 mM Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ADPgammaS
-
 Rattus norvegicus
alpha,beta-methylene-ADP
-
 Rattus norvegicus
AMP
-
 Rattus norvegicus
ATP
-
 Rattus norvegicus
ATPgammaS
-
 Rattus norvegicus
beta,gamma-methylene-ATP
-
 Rattus norvegicus
diadenosine polyphosphate competitive Rattus norvegicus
diethyl dicarbonate
-
 Rattus norvegicus
EDTA drastic reduction of activity Rattus norvegicus
heparin competitive Rattus norvegicus
suramin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Rattus norvegicus 5886
-
synaptosome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required for reactivation of enzyme after treatment with EDTA Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus isoform NPP1 is involved in cleavage of extracellular diadenosine polyphosphates in brain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Renatured (Commentary)

Renatured (Comment) Organism
reactivation of enzyme after treatment with EDTA requires Zn2+ Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain no difference in enzyme activity between young and adult animals Rattus norvegicus
-
central nervous system
-
 Rattus norvegicus
-
cerebellum highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus Rattus norvegicus
-
hippocampus highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus Rattus norvegicus
-
hypothalamus highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diethenoadenosine polyphosphate + H2O
-
 Rattus norvegicus ethenoadenosine 5'-monophosphate + ethenoadenosine (n-1)5'-polyphosphate
-
 ?
additional information isoform NPP1 is involved in cleavage of extracellular diadenosine polyphosphates in brain Rattus norvegicus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9
-
 Rattus norvegicus