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Literature summary for 3.1.4.1 extracted from
- Phosphodiesterases (1963), Methods Enzymol., 6, 236-258.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | 40% inhibition | Sus scrofa |  |
| AMP | 100% inhibition | Sus scrofa | |
| ATP | 20% inhibition | Sus scrofa | |
| EDTA | high concentration | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Sus scrofa | - |
- |
| nucleus | - |
Sus scrofa | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| kidney | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | intestinal mucosa | Sus scrofa | - |
| kidney | - |
Sus scrofa | - |
| liver | - |
Sus scrofa | - |
| lung | - |
Sus scrofa | - |
| mucosa | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 15.5 | 29 | - |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | - |
Sus scrofa | AMP + phosphate | - |
? | |
| ATP + H2O | - |
Sus scrofa | 5'-AMP + diphosphate | - |
? | |
| GDP-mannose + H2O | - |
Sus scrofa | ? | - |
? | |
| additional information | enzyme does not have a strict base specificity, it does not attack oligonucleotides with a 3'-phosphate terminal | Sus scrofa | ? | - |
? | |
| additional information | no activity with p-nitrophenylthymidine 3'-phosphate | Sus scrofa | ? | - |
? | |
| oligonucleotides + H2O | specific for 3'-5'-direction from the 3'-hydroxyl terminal in a stepwise manner | Sus scrofa | oligonucleotides(n-1) + 5'-mononucleotides | - |
? | |
| p-nitrophenylthymidine 5'-phosphate + H2O | - |
Sus scrofa | 5'-TMP + p-nitrophenol | - |
? | |
| UDP-glucose + H2O | - |
Sus scrofa | glucose-1-phosphate + 5'-UMP | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9.5 | - |
Sus scrofa |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.1 | - |
stable above in cold, but rapidly and apparently irreversibly inactivated at pH 4.5 | Sus scrofa |
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