Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-nucleotides | - |
Homo sapiens | |
ADP | - |
Homo sapiens | |
AMP | - |
Homo sapiens | |
CMP | - |
Homo sapiens | |
CoA | - |
Homo sapiens | |
EDTA | completely, inactivation reversed by Ca2+, Co2+ and, at best, with Zn2+ | Homo sapiens | |
GTP | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens | |
NAD+ | - |
Homo sapiens | |
NADH | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens | |
terminal 3'-monophosphoryl group of substrates | - |
Homo sapiens | |
UMP | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
diadenosine 5',5'''-P1,P4-tetraphosphate | Ap4A | Homo sapiens | |
0.001 | - |
diadenosine 5',5'''-P1,P3-triphosphate | Ap3A | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation | Homo sapiens | |
Co2+ | activation | Homo sapiens | |
divalent cations | activation | Homo sapiens | |
Mg2+ | activation | Homo sapiens | |
Ni2+ | slight activation | Homo sapiens | |
Zn2+ | activation | Homo sapiens | |
Zn2+ | physiologically bound | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
16000 | - |
x * 66000 + x * 45000 + x * 16000, enzyme has a complex structure, which is composed of subunits of different size, stoichiometry of the complex is still uncertain, SDS-PAGE | Homo sapiens |
45000 | - |
x * 66000 + x * 45000 + x * 16000, enzyme has a complex structure, which is composed of subunits of different size, stoichiometry of the complex is still uncertain, SDS-PAGE | Homo sapiens |
66000 | - |
x * 66000 + x * 45000 + x * 16000, enzyme has a complex structure, which is composed of subunits of different size, stoichiometry of the complex is still uncertain, SDS-PAGE | Homo sapiens |
230000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
diadenosine polyphosphate + H2O | Homo sapiens | phosphodiesterase can be considered as a catabolic enzyme | AMP + adenosine polyphosphate-1 | - |
? | |
additional information | Homo sapiens | enzyme might function as a modulating factor of platelet aggregation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine 5'-P1-tetraphospho-P4-5'''-adenosine + H2O | - |
Homo sapiens | AMP + ATP | - |
? | |
ATP + H2O | - |
Homo sapiens | 5'-AMP + diphosphate | - |
? | |
diadenosine 5',5'''-P1,P3-triphosphate + H2O | - |
Homo sapiens | AMP + ADP | - |
? | |
diadenosine polyphosphate + H2O | phosphodiesterase can be considered as a catabolic enzyme | Homo sapiens | AMP + adenosine polyphosphate-1 | - |
? | |
dinucleotides + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | no activity with p-nitrophenylthymidine 3'-phosphate | Homo sapiens | ? | - |
? | |
additional information | broad substrate specificity | Homo sapiens | ? | - |
? | |
additional information | enzyme might function as a modulating factor of platelet aggregation | Homo sapiens | ? | - |
? | |
NAD+ + H2O | - |
Homo sapiens | 5'-AMP + NMN | - |
? | |
p-nitrophenylthymidine 5'-phosphate + H2O | - |
Homo sapiens | 5'-TMP + p-nitrophenol | - |
? | |
UTP + H2O | - |
Homo sapiens | UMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 66000 + x * 45000 + x * 16000, enzyme has a complex structure, which is composed of subunits of different size, stoichiometry of the complex is still uncertain, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Ap3A (Ap4A) hydrolase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | 9 | - |
Homo sapiens |