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Literature summary for 3.1.31.1 extracted from

  • Beenken, K.E.; Spencer, H.; Griffin, L.M.; Smeltzer, M.S.
    Impact of extracellular nuclease production on the biofilm phenotype of Staphylococcus aureus under in vitro and in vivo conditions (2012), Infect. Immun., 80, 1634-1638.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.31.1

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular Staphylococcus aureus produces at least two extracellular nucleases Staphylococcus aureus
-
-

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A0H3JPX6 gene nuc2; strain N315, gene nuc2
-
Staphylococcus aureus Q7A6P2 gene nuc1; gene nuc1
-
Staphylococcus aureus N315 Q7A6P2 gene nuc1; gene nuc1
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Staphylococcus aureus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Staphylococcus aureus

General Information

General Information Comment Organism
malfunction mutations of either or both of the nuclease genes nuc1 and nuc2 result in an enhanced capacity to form a biofilm, mutation of nuc2 also has an impact on the ability of a sarA mutant to form a biofilm, at least in the absence of coating with plasma proteins. The susceptibility to daptomycin is reduced in the mutants Staphylococcus aureus
malfunction mutations of either or both of the nuclease genes nuc1 and nuc2 result in an enhanced capacity to form a biofilm. The susceptibility to daptomycin is reduced in the mutants Staphylococcus aureus
metabolism extracellular DNA promotes biofilm formation in Staphylococcus aureus and, conversely, extracellular nucleases limit the ability to form a biofilm Staphylococcus aureus
physiological function extracellular nucleases limit the ability to form a biofilm. The role of extracellular nucleases under in vitro versus in vivo conditions differ Staphylococcus aureus