Protein Variants | Comment | Organism |
---|---|---|
D38V | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
E110Q | the mutation retains 16% of wild type activity | Homo sapiens |
F322L | mutant has similar stability to wild type enzyme | Homo sapiens |
F327del/V338F/I341N/L345R | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
G122D | mutant has similar stability to wild type enzyme | Homo sapiens |
G188D/G188S/G188R | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
G222R | the mutation retains 2.6% of wild type activity | Homo sapiens |
G350X | the mutation retains 41.5% of wild type activity | Homo sapiens |
H119L | the mutation completely abolishes enzymatic activity | Homo sapiens |
H353X | the mutation retains 60% of wild type activity | Homo sapiens |
K355X | the mutation retains 65% of wild type activity | Homo sapiens |
K76N | the mutation completely abolishes enzymatic activity | Homo sapiens |
L349X | the mutation retains 5.3% of wild type activity | Homo sapiens |
N264K/L265P/G266V/G270V/G270R | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
P257L | the mutation retains 6.1% of wild type activity | Homo sapiens |
Q347X | the mutation completely inactivates the G6PC enzyme | Homo sapiens |
Q351X | the mutation retains 43% of wild type activity | Homo sapiens |
R170Q | the mutation completely abolishes enzymatic activity | Homo sapiens |
R170X | the mutation completely inactivates the G6PC enzyme | Homo sapiens |
R295C/S298P | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
R83C | the mutation completely abolishes enzymatic activity | Homo sapiens |
R83H | the mutation completely abolishes enzymatic activity | Homo sapiens |
V166A | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
W63R/G68R | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
Y209C/L211P/G222R | the mutation leads to reduced levels of G6PC protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35575 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | - |
Homo sapiens | D-glucose + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G6PC | - |
Homo sapiens |
glucose-6-phosphatase-alpha | - |
Homo sapiens |