Application | Comment | Organism |
---|---|---|
medicine | inhibitory effect of silibinin on both hepatic glucose-6-phosphatase and gluconeogenesis may be of interest in treatment of type 2 diabetes | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
silibinin | induces a dose-dependent inhibition of gluconeogenesis associated with a potent decrease in enzyme activity; inhibits gluconeogenesis and D-glucose 6-phosphate hydrolysis from either lactate/pyruvate, glycerol or fructose in a dose-dependent manner. Effect is stronger in intact than in permeabilized microsomes | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.8 | - |
D-glucose 6-phosphate | control, intact microsomes | Rattus norvegicus | |
5.3 | - |
D-glucose 6-phosphate | intact microsomes incubated with silibinin | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | microsome | Rattus norvegicus | - |
hepatocyte | perifused hepatocyte | Rattus norvegicus | - |
liver | perifused hepatocyte | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | - |
Rattus norvegicus | D-glucose + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G6Pase | - |
Rattus norvegicus |
glucose-6-phosphatase | - |
Rattus norvegicus |