Literature summary for 3.1.3.9 extracted from

Pedersen, K.B.; Zhang, P.; Doumen, C.; Charbonnet, M.; Lu, D.; Newgard, C.B.; Haycock, J.W.; Lange, A.J.; Scott, D.K.
The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions (2007), Am. J. Physiol. Endocrinol. Metab., 292, E788-E801.

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Activating Compound

Activating Compound	Comment	Organism	Structure
D-glucose	induces the expression of G-6-Pase at transcriptional and posttranscriptional levels, strongly increases endogenous G-6-Pase mRNA levels in 832/13 cells and in rat pancreatic islets. Induced levels from islets are still markedly lower than in untreated primary hepatocytes	Rattus norvegicus
additional information	distinct cis-regulatory promoter elements are involved in the glucose response of the rat G-6-Pase gene. Full-length (-4078/+64) promoter confers a moderate glucose response to a reporter construct in HL1C rat hepatoma cells, which is dependent on coexpression of glucokinase. The same construct provides a robust glucose response in 832/13 INS-1 rat insulinoma cells, which are not glucogenic	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	expression of dominant-negative versions of both cAMP response element-binding protein and CAAT/enhancer-binding protein blocks the glucose response of the proximal region in a dose-dependent manner	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL1C cell	-	Rattus norvegicus	-
INS-1 823/13 cell	-	Rattus norvegicus	-
pancreatic islet	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose 6-phosphate + H2O	-	Rattus norvegicus	D-glucose + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
G-6-Pase	-	Rattus norvegicus
glucose-6-phosphatase	-	Rattus norvegicus

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Release 2023.1 (January 2023)