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Literature summary for 3.1.3.9 extracted from

  • Methieux, G.; Zitoun, C.
    Mechanisms by which fatty-acyl-CoA esters inhibit or activate glucose-6-phosphasaes in intact and detergent-treated rat liver microsomes (1996), Eur. J. Biochem., 235, 799-803.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
fatty-acyl-CoA with chain-length equal to or higher than 16, at 0.001-0.002 mM, the inhibitory effect on the enzyme of untreated microsomes is either partially or totally cancelled, or even changes into an activation effect at higher concentrations, the inhibition is fully reversible in presence of bovine serum albumin. With medium chain-length, 10-14 carbons inhibit the enzyme of untreated microsomes in a dose-dependent manner in the range 0.001-0.02 mM, the higher the chain length, the stronger the inhibitory effect Rattus norvegicus
myristoyl-CoA uncompetitive inhibition of enzyme in untreated microsomes, non-competitive inhibition of enzyme from detergent-treated microsomes Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
 Rattus norvegicus D-glucose + phosphate
-
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