Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Danio rerio | - |
Synonyms | Comment | Organism |
---|---|---|
SH2-domain-containing 5-inositol phosphatase | - |
Danio rerio |
SHIP | - |
Danio rerio |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of SHIP 5'-phosphatases increases neutrophil wound attraction and random motility through a PI3K-dependent pathway. Ectopic expression of the SHIP1 phosphatase domain impairs neutrophil migration | Danio rerio |
physiological function | SHIP phosphatases serve as a brake that limit neutrophil motility and inflammation, at least in part through their effects on PI3K signaling | Danio rerio |