Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.7 extracted from

  • Li, W.; Jia, H.; Li, Q.; Cui, J.; Li, R.; Zou, Z.; Hong, X.
    Glycerophosphatidylcholine PC(36 1) absence and 3'-phosphoadenylate (pAp) accumulation are hallmarks of the human glioma metabolome (2018), Sci. Rep., 8, 14783 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.7

Organism

Organism UniProt Comment Textmining
Homo sapiens O95861
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell in glioma tissues, phosphocholine(36:1) is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated, quantitative real-time polymerase chain reaction (qRT-PCR) expression analysis. Gene expression of enzymes associated with pAp metabolism Homo sapiens
-

Synonyms

Synonyms Comment Organism
3'(2'),5'-bisphosphate nucleotidase 1
-
 Homo sapiens
BPNT-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in glioma tissues, glycerophosphatidylcholine [PC(36:1)] is not detected and 3'-phosphoadenylate content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated down

General Information

General Information Comment Organism
malfunction in glioma tissues, glycerophosphatidylcholine [PC(36:1)] is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expressions of 3'-nucleotidases inositol monophosphatase (IMPAD-1) and 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1)) are dramatically downregulated. Dramatic downregulation of IMPAD-1 and BPNT-1 are the primary cause for pAp dramatic accumulation Homo sapiens
physiological function Gene expression of enzymes associated with 3'-phosphoadenylate (pAp) metabolism, pAp is a toxic by-product Homo sapiens