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Literature summary for 3.1.3.7 extracted from

  • Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.
    New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus (2016), J. Biol. Chem., 291, 26970-26986 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.7

Inhibitors

Inhibitors Comment Organism Structure
guanosine pentaphosphate
-
 Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Staphylococcus aureus 5737
-

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A0H2XFX6
-
-
Staphylococcus aureus USA300 A0A0H2XFX6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-bisphosphate + H2O
-
 Staphylococcus aureus AMP + phosphate
-
 ?
adenosine 3',5'-bisphosphate + H2O
-
 Staphylococcus aureus USA300 AMP + phosphate
-
 ?
additional information isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP Staphylococcus aureus ?
-
 ?
additional information isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP Staphylococcus aureus USA300 ?
-
 ?

Synonyms

Synonyms Comment Organism
PDE2
-
 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function a Pde2 mutant strain displays a growth defect in the early growth phase. Mutation leads to an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased resistance to oxacillin Staphylococcus aureus