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Literature summary for 3.1.3.67 extracted from

  • Qiu, W.; Federico, L.; Naples, M.; Avramoglu, R.K.; Meshkani, R.; Zhang, J.; Tsai, J.; Hussain, M.; Dai, K.; Iqbal, J.; Kontos, C.D.; Horie, Y.; Suzuki, A.; Adeli, K.
    Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins (2008), Hepatology, 48, 1799-1809.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.67

Cloned(Commentary)

Cloned (Comment) Organism
adenovirus expressing PTEN wild-type, encoding full-length human wild-type PTEN cDNA and AdPTENC/S, encoding a dominant negative human PTEN cDNA mutant (cysteine 124 changed to serine within the catalytic domain) are used for the transduction of cell cultures, overexpression of PTEN and its mutant Homo sapiens
PTEN liver-specific knock-out mice are generated Mus musculus

Protein Variants

Protein Variants Comment Organism
C124S adenovirus encoding a dominant negative human PTEN cDNA is used for the transduction of cell cultures Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus loss of PTEN in the liver creates a state in which the phosphatidylinositol-3 kinase pathway is constitutively active, leading to chronic suppression of apolipoprotein B 100 and mitogen-activated protein resulting in reduced very low-density lipoprotein assembly and hepatic secretion of triglyceride ?
-
 ?
additional information Homo sapiens overexpression of PTEN modulates the basal activities of both phosphoinositide 3 kinase-AKT and mitogen-activated protein kinase-extracellular signal-regulated kinase cascades ?
-
 ?
additional information Mus musculus PTEN activity may control the stability and cellular availability of newly synthesized hepatic apolipoprotein B100 at least partially through modulation of microsomal triglyceride transfer protein ?
-
 ?
additional information Mus musculus PTEN liver-specific knockout mice have fatty liver, increased triglyceride content and reduced apolipoprotein B protein mass ?
-
 ?
additional information Homo sapiens PTEN regulates basal activities of the phosphoinositide 3-kinase-AKT8 virus oncogene cellular homolog and extracellular signal-regulated kinase cascades, independent of insulin stimulation ?
-
 ?
additional information Mus musculus PTEN regulates hepatic lipogenesis, microsomal triglyceride transfer protein and the secretion of apolipoprotein B-containing lipoproteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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liver
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 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 loss of PTEN activity in knockout mice modell leads to activation of lipogenesis, as evidences from increased mRNA levels for sterol regulatory element binding protein 1c, fatty acid synthase and acetyl-CoA carboxylase Mus musculus
additional information
-
 loss of PTEN activity in the Hep-G2 cell line leads to activation of lipogenesis, as evidenced from increased mRNA levels for sterol regulatory element binding protein 1c, fatty acid synthase and acetyl-CoA carboxylase Homo sapiens
additional information
-
 modulation of PTEN influences the microsomal triglyceride transfer protein mass and lipid transfer activity Mus musculus
additional information
-
 modulation of PTEN influences the microsomal triglyceride transfer protein mass and lipid transfer activity Homo sapiens
additional information
-
 protein levels of PTEN in the liver of 13-week-old male mice with PTEN liver-specific knockout are significantly decreased to 16% of that in the control mice Mus musculus
additional information
-
 PTEN overactivity have a profound inhibitory effect on insulin signaling downstream of phosphatidylinositol-3 kinase and can readily induce insulin resistance Mus musculus
additional information
-
 PTEN protein levels are significantly increased in a dose-dependent manner with PTEN wildtype and PTEN C124S mutant overexpression at both 5 and 20 multiplicity of infection (moi) in Hep-G2 cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information loss of PTEN in the liver creates a state in which the phosphatidylinositol-3 kinase pathway is constitutively active, leading to chronic suppression of apolipoprotein B 100 and mitogen-activated protein resulting in reduced very low-density lipoprotein assembly and hepatic secretion of triglyceride Mus musculus ?
-
 ?
additional information overexpression of PTEN modulates the basal activities of both phosphoinositide 3 kinase-AKT and mitogen-activated protein kinase-extracellular signal-regulated kinase cascades Homo sapiens ?
-
 ?
additional information PTEN activity may control the stability and cellular availability of newly synthesized hepatic apolipoprotein B100 at least partially through modulation of microsomal triglyceride transfer protein Mus musculus ?
-
 ?
additional information PTEN liver-specific knockout mice have fatty liver, increased triglyceride content and reduced apolipoprotein B protein mass Mus musculus ?
-
 ?
additional information PTEN regulates basal activities of the phosphoinositide 3-kinase-AKT8 virus oncogene cellular homolog and extracellular signal-regulated kinase cascades, independent of insulin stimulation Homo sapiens ?
-
 ?
additional information PTEN regulates hepatic lipogenesis, microsomal triglyceride transfer protein and the secretion of apolipoprotein B-containing lipoproteins Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphatase and tensin homolog
-
 Mus musculus
phosphatase and tensin homolog
-
 Homo sapiens
PTEN
-
 Mus musculus
PTEN
-
 Homo sapiens