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Literature summary for 3.1.3.67 extracted from

  • Rankin, S.L.; Guy, C.S.; Mearow, K.M.
    PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1 (2009), Biochem. Biophys. Res. Commun., 379, 721-725.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
GFP-tagged wild-type, C124S and G129E mutant PTEN are constructed Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
C124S PTEN mutant is devoid of phosphatase activity and fails to modulate p75NTR expression, indicating that phosphatase activity is required for PTEN regulation of neurotophin receptor p75NTR Rattus norvegicus
G129E PTEN mutant which is lipid phosphatase dead but which retains protein phosphatase activity, significantly reduces the expression of p75NTR, suggesting that it is the protein phosphatase activity of PTEN that is able to regulate neurotophin receptor p75NTR expression Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Laminin laminin medium induces PTEN upregulation decreases transcription factor Sp1-binding activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Rattus norvegicus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PTEN directly downregulates neurotophin receptor (p75NTR) expression by decreasing DNA-binding activity of transcription factor Sp1 ?
-
?
additional information Rattus norvegicus PTEN is a dual specificity phosphatase capable of dephosphorylating both lipid and protein substrates ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell pheochromocytoma cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PTEN directly downregulates neurotophin receptor (p75NTR) expression by decreasing DNA-binding activity of transcription factor Sp1 Rattus norvegicus ?
-
?
additional information PTEN is a dual specificity phosphatase capable of dephosphorylating both lipid and protein substrates Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
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Rattus norvegicus
PTEN
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Rattus norvegicus