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Literature summary for 3.1.3.67 extracted from

  • Maehama, T.; Dixon, J.E.
    The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate (1998), J. Biol. Chem., 273, 13375-13378.
    View publication on PubMed
Search for more literature for 3.1.3.67

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
C124S complete loss of activity towards inositol 1,3,4,5-tetrakisphosphate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0989
-
 Inositol 1,3,4,5-tetrakisphosphate
-
 Homo sapiens
25.6
-
 4-nitrophenyl phosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Phosphatidylinositol-3,4,5-trisphosphate + H2O Homo sapiens it is possible that the enzyme acts in vivo as a phosphoinositide 3-phosphatase by regulating phosphatidylinositol-3,4,5-trisphosphate levels Phosphatidyl inositol-4,5-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens inositol 1,4,5-trisphosphate + phosphate
-
 ?
phosphatidylinositol 3-phosphate + H2O at 20% of the activity with phosphatidylinositol-3,4,5-trisphosphate Homo sapiens phosphatidylinositol + phosphate
-
 ?
Phosphatidylinositol-3,4,5-trisphosphate + H2O
-
 Homo sapiens Phosphatidyl inositol-4,5-bisphosphate + phosphate
-
 ?
Phosphatidylinositol-3,4,5-trisphosphate + H2O it is possible that the enzyme acts in vivo as a phosphoinositide 3-phosphatase by regulating phosphatidylinositol-3,4,5-trisphosphate levels Homo sapiens Phosphatidyl inositol-4,5-bisphosphate + phosphate
-
 ?
phosphatidylinostitol 3,4-bisphosphate + H2O at 20% of the activity with phosphatidylinositol-3,4,5-trisphosphate Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PTEN/MMAC1
-
 Homo sapiens