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Literature summary for 3.1.3.67 extracted from

  • Maier, D.; Jones, G.; Li, X.; Schonthal, A.H.; Gratzl, O.; Van Meir, E.G.; Merlo, A.
    The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells (1999), Cancer Res., 59, 5479-5482.
    View publication on PubMed
Search for more literature for 3.1.3.67

Protein Variants

Protein Variants Comment Organism
C124S catalytically inactive mutant enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens phosphatase-independent domains of PTEN markedly reduce the invasive potential of glioma cells, defining a structural role for PTEN that regulates cell motility distinct of the PKB/Akt pathway ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LN-229 cell infiltrative glioma cell line Homo sapiens
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additional information infiltrative glioma cell line U87MG lacks functional PTEN Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphatase-independent domains of PTEN markedly reduce the invasive potential of glioma cells, defining a structural role for PTEN that regulates cell motility distinct of the PKB/Akt pathway Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
tumor suppressor PREN
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 Homo sapiens