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Literature summary for 3.1.3.66 extracted from

  • Hodgson, M.C.; Shao, L.J.; Frolov, A.; Li, R.; Peterson, L.E.; Ayala, G.; Ittmann, M.M.; Weigel, N.L.; Agoulnik, I.U.
    Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer (2011), Cancer Res., 71, 572-582.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene INPP4B
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
additional information INPP4B expression is evaluated by quantitative RT-PCR Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-
prostate gland
-
 Homo sapiens
-
VCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
 ?
additional information inositol polyphosphate 4-phosphatase type II is a class II phosphatase that preferentially hydrolyzes the 4 position of PI(3,4)P2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
inositol polyphosphate 4-phosphatase type II
-
 Homo sapiens
INPP4B
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens optimal induction of INPP4B by an androgen receptor required the expression of the transcriptional coactivator NCoR up

General Information

General Information Comment Organism
malfunction silenced INPP4B expression in malignant proerythroblast is associated with increased activated-Akt levels that can be alleviated by the reexpression of INPP4B. Knockdown of INPP4B in LNCaP cells enhances proliferation Homo sapiens
additional information INPP4B is regulated by androgens at the level of transcription. INPP4B mRNA expression is induced in both LNCaP and VCaP AR-expressing prostate cancer cells. INPP4B and PTEN expression are correlated with the recurrence rate of patients with high and low expression levels of the proliferation marker Ki67 Homo sapiens
physiological function INPP4B regulates proliferation and Akt phosphorylation in prostate cancer cells Homo sapiens