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Literature summary for 3.1.3.66 extracted from

  • Marjanovic, J.; Wilson, M.; Zhang, C.; Zou, J.; Nicholas, P.; Majerus, P.
    The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model (2011), Adv. Enzyme Regul., 51, 101-105.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O Mus musculus
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 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol polyphosphate 4-phosphatase 1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ananlysis of the role of 4-phosphatase I in the regulation of PtdIns(3,4)P2 in platelets in the weeble mouse model, the mice are viable, but lack platelet 4-phosphatase I, overview. Weeble chimeric mice have a propensity for thrombosis using a carotid artery injury model Mus musculus
physiological function PtdIns(3,4)P2 is important for platelet function and stabilizes platelet aggregates, role of inositol polyphosphate 4-phosphatase 1 in regulation of PtdIns(3,4)P2 and of platelet function, overview Mus musculus