Literature summary for 3.1.3.66 extracted from

Ivetac, I.; Munday, A.D.; Kisseleva, M.V.; Zhang, X.M.; Luff, S.; Tiganis, T.; Whisstock, J.C.; Rowe, T.; Majerus, P.W.; Mitchell, C.A.
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane (2005), Mol. Biol. Cell, 16, 2218-2233.

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Protein Variants

Protein Variants	Comment	Organism
additional information	C2-domain deletion mutant, loss of enzyme activity, no localization to endosomes, no TAPP1 PH domain membrane recruitment	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endosome	early and recycling endosome	Homo sapiens	5768	-
plasma membrane	and endosome, after growth factor stimulation	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O	-	Homo sapiens	1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate	-	?

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Release 2023.1 (January 2023)