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Literature summary for 3.1.3.6 extracted from
- An inducible 3'-nucleotidase/nuclease from the trypanosomatid Crithidia luciliae. Purification and characterization (1990), J. Biol. Chem., 265, 7236-7242.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | leishmanial 3'-nucleotidase could become a target for chemotherapeutic attack because an enzyme with similar properties has not been detected in mammalian tissues | Crithidia luciliae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Crithidia luciliae |  |
| EDTA | - |
Crithidia luciliae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Crithidia luciliae | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
x * 43000, SDS-PAGE | Crithidia luciliae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crithidia luciliae | - |
ATTC 30258 | - |
| Crithidia luciliae ATTC 30258 | - |
ATTC 30258 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Crithidia luciliae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2310 | - |
- |
Crithidia luciliae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-AMP + H2O | - |
Crithidia luciliae | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Crithidia luciliae ATTC 30258 | adenosine + phosphate | - |
? | |
| 3'-CMP + H2O | 2% of the activity with 3'-AMP | Crithidia luciliae | cytosine + phosphate | - |
? | |
| 3'-CMP + H2O | 2% of the activity with 3'-AMP | Crithidia luciliae ATTC 30258 | cytosine + phosphate | - |
? | |
| 3'-GMP + H2O | 6% of the activity with 3'-AMP | Crithidia luciliae | guanosine + phosphate | - |
? | |
| 3'-GMP + H2O | 6% of the activity with 3'-AMP | Crithidia luciliae ATTC 30258 | guanosine + phosphate | - |
? | |
| 3'-UMP + H2O | 44% of the activity with 3'-AMP | Crithidia luciliae | uridine + phosphate | - |
? | |
| 3'-UMP + H2O | 44% of the activity with 3'-AMP | Crithidia luciliae ATTC 30258 | uridine + phosphate | - |
? | |
| adenosine 3',5'-diphosphate + H2O | - |
Crithidia luciliae | ? | - |
? | |
| adenosine 3',5'-diphosphate + H2O | - |
Crithidia luciliae ATTC 30258 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000, SDS-PAGE | Crithidia luciliae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Crithidia luciliae |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 7 | Zn2+ protects against inactivation at pH 5.0 | Crithidia luciliae |
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