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Literature summary for 3.1.3.53 extracted from

  • Shichi, D.; Arimura, T.; Ishikawa, T.; Kimura, A.
    Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1 (2010), J. Biol. Chem., 285, 33680-33690.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged full-length catalytic subunit MYPT1 in COS-7 cells, co-expression with Rho-associated kinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein myosin light chain phosphatase is regulated by phosphorylation of the catalytic subunit Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart
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 Homo sapiens
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Subunits

Subunits Comment Organism
trimer myosin light chain phosphatase consists of a catalytic subunit, a large subunit, MYPT1 or MYPT2, and a small subunit Homo sapiens

Synonyms

Synonyms Comment Organism
mLC phosphatase
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 Homo sapiens
MLCP
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 Homo sapiens
myosin light chain phosphatase
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 Homo sapiens

General Information

General Information Comment Organism
additional information myosin light chain phosphatase is regulated by phosphorylation of the catalytic subunit, the heart-specific small subunit, hHS-M21, plays a role in the regulation by phosphorylation, molecular mechanism, overview. Two isoforms of hHSM21, hHS-M21Aand hHS-M21B, preferentially bound the C-terminal one-third region of MYPT1 and MYPT2, respectively. Amino acid substitutions at a phosphorylation site of MYPT1, Ser852, impaired the binding of MYPT1 and hHS-M21. The hHS-M21 increases the phosphorylation level of MYPT1 at Thr696, which is attenuated by Rho-associated kinase, ROCK, inhibitors and small interfering RNAs for Rho-associated kinase Homo sapiens
physiological function the heart-specific small subunit, hHS-M21, is a heart-specific effector of Rho-associated kinase and plays a regulatory role in the MYPT1 phosphorylation at Thr-696 by Rho-associated kinase, molecular mechanism, overview Homo sapiens