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Literature summary for 3.1.3.53 extracted from
- Myosin light chain kinases and phosphatase in mitosis and cytokinesis (2011), Arch. Biochem. Biophys., 510, 76-82.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| myosin phosphatase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme domain MYPT mutation, MEL-11, causes cytokinesis failure | Homo sapiens |
| physiological function | myosin phosphatase is required for contractile ring disassembly at the end of cytokinesis, it is involved in the assembly of ring canals derived from incomplete cytokinesis and function as intracellular bridges between nurse cells, thereby allowing cytoplasmic flow from nurse cells to oocytes. Myosin phosphatase must be temporally controlled during cytokinesis: it is first inactivated for the activation of a contractile ring at the initial stage of cytokinesis and then inactivated for the disassembly of the contractile ring | Homo sapiens |
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Release 2023.1 (January 2023)
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