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Literature summary for 3.1.3.53 extracted from

  • Ratz, P.H.; Miner, A.S.
    Role of protein kinase Czeta and calcium entry in KCl-induced vascular smooth muscle calcium sensitization and feedback control of cellular calcium levels (2009), J. Pharmacol. Exp. Ther., 328, 399-408.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine H-1152, 0.0003 mM produces a strong inhibition of basal MYPT1-pT853 by nearly 75%, KCl produces an approximate 1.75-2fold increase in MYPT1-pT853 in the presence and absence of H-1152 Oryctolagus cuniculus
CPI-17 17-kDa protein kinase C-dependent MLCP inhibitor Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
Oryctolagus cuniculus
-
vascular smooth muscle cell
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myosin light-chain phosphate + H2O
-
Oryctolagus cuniculus myosin light-chain + phosphate
-
?

Synonyms

Synonyms Comment Organism
MLCP
-
Oryctolagus cuniculus
myosin light chain phosphatase
-
Oryctolagus cuniculus
MYPT1-pT853 myosin light-chain phosphatase-targeting subunit at Thr853 Oryctolagus cuniculus