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Literature summary for 3.1.3.53 extracted from

  • Lee, E.; Hayes, D.B.; Langsetmo, K.; Sundberg, E.J.; Tao, T.C.
    Interactions between the leucine-zipper motif of cGMP-dependent protein kinase and the C-terminal region of the targeting subunit of myosin light chain phosphatase (2007), J. Mol. Biol., 373, 1198-1212.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.53

Cloned(Commentary)

Cloned (Comment) Organism
in Escherichia coli, expression of various C-terminal MYPT1 peptides bearing various combinations of a predicted coiled coil region, extensions preceding this coiled coil region, and the leucine-zipper motif Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
of the recombinant peptides by chitin beads Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
aortic smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myosin light-chain phosphate + H2O muscle Homo sapiens myosin light-chain + phosphate
-
 ?

Subunits

Subunits Comment Organism
More The leucine-zipper motif at the N terminus of PKG forms a homodimeric coiled coil, the one at the C terminus of MYPT1 is monomeric and non-helical. The leucine-zipper motif of PKG binds to that of MYPT1 to form a heterodimer. When the leucine-zipper motif of MYPT1 is absent, the PKG leucine-zipper motif binds to the coiled coil region and upstream segments of MYPT1 via formation of a heterotetramer Homo sapiens

Synonyms

Synonyms Comment Organism
MLCP
-
 Homo sapiens
myosin light chain phosphatase
-
 Homo sapiens
MYPT1 the targeting subunit of MLCP Homo sapiens