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Literature summary for 3.1.3.53 extracted from

  • Muranyi, A.; Erdodi, F.; Ito, M.; Gergely, P.; Hartshorne, D.J.
    Identification and localization of myosin phosphatase in human platelets (1998), Biochem. J., 330, 225-231.
No PubMed abstract available
Search for more literature for 3.1.3.53

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid at 1 nM almost complete inhibition of PP-2A Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoskeleton platelet, only PP-1, not PP-2A Homo sapiens 5856
-
additional information localization of PP-1 and PP-2A and their subunits in platelets Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens plays a key role in platelet function ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 PP-1 and PP-2A
-

Source Tissue

Source Tissue Comment Organism Textmining
platelet from venous blood, myosin phosphatase in platelets is composed of the catalytic subunit of PP-1 plus a subunit similar to the 130 kDa regulatory myosin-binding subunit of the smooth muscle phosphatase, major phosphatase is PP-1, also PP-2A Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information plays a key role in platelet function Homo sapiens ?
-
 ?
myosin light-chain phosphate + H2O 20 kDa myosin light chain Homo sapiens myosin light-chain + phosphate
-
 ?
phosphorylated phoshorylase A + H2O
-
 Homo sapiens phosphorylase A + phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens