Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | pulmonary hypertension down-regulates pulmonary vascular MLCP expression | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Ovis aries | pulmonary hypertension down-regulates pulmonary vascular MLCP expression, the maintenance of a high pulmonary vascular resistance may be secondary to abnormalities in tissue content and/or activity of MLCP | ? | - |
? | |
myosin light-chain phosphate + H2O | Ovis aries | key smooth muscle regulatory protein, MLCP is required for muscle relaxation | myosin light-chain + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
normal and pulmonary hypertensive fetal sheep, MLCP, protein phosphatase type 1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | fetal, same MLCP activities in normal and pulmonary hypertensive fetal sheep | Ovis aries | - |
fetus | normal and pulmonary hypertensive fetal sheep, pulmonary artery, aorta and vena cava | Ovis aries | - |
pulmonary artery | fetal, MLCP activity in pulmonary hypertensive fetal sheep is significantly lower than in normal fetal sheep | Ovis aries | - |
vena cava | fetal, same MLCP activities in normal and pulmonary hypertensive fetal sheep | Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | pulmonary hypertension down-regulates pulmonary vascular MLCP expression, the maintenance of a high pulmonary vascular resistance may be secondary to abnormalities in tissue content and/or activity of MLCP | Ovis aries | ? | - |
? | |
myosin light-chain phosphate + H2O | from turkey gizzard | Ovis aries | myosin light-chain + phosphate | - |
? | |
myosin light-chain phosphate + H2O | 20 kDa myosin light chain | Ovis aries | myosin light-chain + phosphate | - |
? | |
myosin light-chain phosphate + H2O | key smooth muscle regulatory protein, MLCP is required for muscle relaxation | Ovis aries | myosin light-chain + phosphate | - |
? | |
phosphorylated heavy meromyosin + H2O | from turkey gizzard | Ovis aries | heavy meromyosin + phosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Ovis aries |