Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.5 extracted from

  • Peng, Z.; Fernandez, P.; Wilder, T.; Yee, H.; Chiriboga, L.; Chan, E.S.; Cronstein, B.N.
    Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis (2008), FASEB J., 22, 2263-2272.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CCl4 livers from wild type mice treated with CCl4 (1.25 ml/kg) release 2-3fold higher levels of adenosine than livers from comparably treated CD73KO mice Mus musculus
ethanol livers from wild type mice treated with ethanol (2 g/kg of 20% ethanol) release 2-3fold higher levels of adenosine than livers from comparably treated CD73KO mice Mus musculus
Thioacetamide livers from wild type mice treated with thioacetamide (100 mg/kg) release 2-3fold higher levels of adenosine than livers from comparably treated CD73KO mice Mus musculus

Application

Application Comment Organism
medicine CD73 plays an important role in adenosine generation in the liver, the extracellular adenosine generated by CD73 is a critical mediator of hepatic fibrosis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
Mus musculus adenosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
CD73
-
Mus musculus
ecto-5'-nucleotidase
-
Mus musculus