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Literature summary for 3.1.3.48 extracted from

  • Sun, G.; Cheng, S.Y.; Chen, M.; Lim, C.J.; Pallen, C.J.
    Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions (2012), Mol. Cell. Biol., 32, 3776-3789.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Mus musculus
-
[a protein]-tyrosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated BCAR3 + H2O
-
Mus musculus BCAR3 + phosphate
-
?
[a protein]-tyrosine phosphate + H2O
-
Mus musculus [a protein]-tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase alpha
-
Mus musculus
PTPalpha
-
Mus musculus

General Information

General Information Comment Organism
physiological function protein tyrosine phosphatase (PTP) alpha regulates integrin signaling, focal adhesion formation, and migration. PTPalpha-Tyr789 is necessary for efficient integrin-induced Cas tyrosine phosphorylation and Cas-Crk association, and regulates Cas downstream signaling events and Cas localization to focal adhesions Mus musculus