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Literature summary for 3.1.3.48 extracted from

  • He, Y.; Xu, J.; Yu, Z.H.; Gunawan, A.M.; Wu, L.; Wang, L.; Zhang, Z.Y.
    Discovery and evaluation of novel inhibitors of Mycobacterium protein tyrosine phosphatase B from the 6-hydroxy-benzofuran-5-carboxylic acid scaffold (2013), J. Med. Chem., 56, 832-842.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
6-hydroxy-2-phenyl-3-((3-trifluoromethyl)phenyl)benzofuran-5-carboxylic acid most potent, reversible and noncompetitive inhibitor, highly selective towards isoform PTPB Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Mycobacterium tuberculosis
-
[a protein]-tyrosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Mycobacterium tuberculosis 4-nitrophenol + phosphate
-
?
[a protein]-tyrosine phosphate + H2O
-
Mycobacterium tuberculosis [a protein]-tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase B
-
Mycobacterium tuberculosis
PtpB
-
Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000044
-
6-hydroxy-2-phenyl-3-((3-trifluoromethyl)phenyl)benzofuran-5-carboxylic acid at 25°C in 50 mM 3,3-dimethylglutarate buffer, pH 7.0 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function protein tyrosine phosphatase B is a virulence factor secreted into the host macrophage Mycobacterium tuberculosis