Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-hydroxy-2-phenyl-3-((3-trifluoromethyl)phenyl)benzofuran-5-carboxylic acid | most potent, reversible and noncompetitive inhibitor, highly selective towards isoform PTPB | Mycobacterium tuberculosis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[a protein]-tyrosine phosphate + H2O | Mycobacterium tuberculosis | - |
[a protein]-tyrosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Mycobacterium tuberculosis | 4-nitrophenol + phosphate | - |
? | |
[a protein]-tyrosine phosphate + H2O | - |
Mycobacterium tuberculosis | [a protein]-tyrosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase B | - |
Mycobacterium tuberculosis |
PtpB | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000044 | - |
6-hydroxy-2-phenyl-3-((3-trifluoromethyl)phenyl)benzofuran-5-carboxylic acid | at 25°C in 50 mM 3,3-dimethylglutarate buffer, pH 7.0 | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | protein tyrosine phosphatase B is a virulence factor secreted into the host macrophage | Mycobacterium tuberculosis |