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Literature summary for 3.1.3.48 extracted from

  • Hu, X.; Vujanac, M.; Southall, N.; Stebbins, C.E.
    Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches (2013), Bioorg. Med. Chem. Lett., 23, 1056-1062.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-[1-carbamothioyl-3-(4-nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]-1-(4-sulfophenyl)diazanide
-
Yersinia pestis
(2E)-2-[[5-(3-carboxy-4-hydroxycyclohexa-1,5-dien-1-yl)furan-2-yl]methylidene]-1-[6-[(4-fluorophenyl)amino][1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]diazanide
-
Yersinia pestis
(3Z)-5-bromo-3-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
-
Yersinia pestis
(4-fluorophenyl)[[(Z)-(2,2,2-trifluoro-1-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]ethylidene)amino]oxy]methanone
-
Yersinia pestis
(4E)-2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzylidene)-1,3-oxazol-5(4H)-one
-
Yersinia pestis
1,6-dimethyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
Yersinia pestis
1-[(5Z)-5-(1-butyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
-
Yersinia pestis
1-[4-[(2-nitrophenyl)sulfonyl]piperazin-1-yl]-2-phenoxyethanone
-
Yersinia pestis
2-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]-1H-indene-1,3(2H)-dione
-
Yersinia pestis
3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
-
Yersinia pestis
4-[1,3-dioxo-5-(4-oxo-4H-3,1-benzoxazin-2-yl)-1,3-dihydro-2H-isoindol-2-yl]benzoate
-
Yersinia pestis
4-[4,5-di(biphenyl-4-yl)-1H-imidazol-2-yl]benzoic acid
-
Yersinia pestis
5,7-bis[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2-methyltetrazolo[1,5-a]pyrimidin-2-ium
-
Yersinia pestis
5-([(E)-[2-(4-chlorophenyl)-5-oxo-1,3-oxazol-4(5H)-ylidene]methyl]amino)-2-hydroxybenzoic acid
-
Yersinia pestis
5-([1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indol-3-yl]methylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
-
Yersinia pestis
5-[3-bromo-4-[(4-nitrobenzyl)oxy]benzylidene]pyrimidine-2,4,6(1H,3H,5H)-trione
-
Yersinia pestis
5-[4-(3,4-dihydroisoquinolin-2(1H)-yl)-3-nitrobenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
Yersinia pestis
5-[4-[(2-chloro-6-fluorobenzyl)oxy]benzylidene]-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
-
Yersinia pestis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Yersinia pestis
-
[a protein]-tyrosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Yersinia pestis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[a protein]-tyrosine phosphate + H2O
-
Yersinia pestis [a protein]-tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
Yersinia pestis
YopH
-
Yersinia pestis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00038
-
pH and temperature not specified in the publication Yersinia pestis (2E)-2-[[5-(3-carboxy-4-hydroxycyclohexa-1,5-dien-1-yl)furan-2-yl]methylidene]-1-[6-[(4-fluorophenyl)amino][1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]diazanide
0.00088
-
pH and temperature not specified in the publication Yersinia pestis 1,6-dimethyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
0.00098
-
pH and temperature not specified in the publication Yersinia pestis 1-[4-[(2-nitrophenyl)sulfonyl]piperazin-1-yl]-2-phenoxyethanone
0.00122
-
pH and temperature not specified in the publication Yersinia pestis (3Z)-5-bromo-3-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
0.00128
-
pH and temperature not specified in the publication Yersinia pestis 3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
0.00168
-
pH and temperature not specified in the publication Yersinia pestis 1-[(5Z)-5-(1-butyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
0.00189
-
pH and temperature not specified in the publication Yersinia pestis 5-[3-bromo-4-[(4-nitrobenzyl)oxy]benzylidene]pyrimidine-2,4,6(1H,3H,5H)-trione
0.00192
-
pH and temperature not specified in the publication Yersinia pestis 4-[1,3-dioxo-5-(4-oxo-4H-3,1-benzoxazin-2-yl)-1,3-dihydro-2H-isoindol-2-yl]benzoate
0.00215
-
pH and temperature not specified in the publication Yersinia pestis 4-[4,5-di(biphenyl-4-yl)-1H-imidazol-2-yl]benzoic acid
0.00235
-
pH and temperature not specified in the publication Yersinia pestis (4-fluorophenyl)[[(Z)-(2,2,2-trifluoro-1-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]ethylidene)amino]oxy]methanone
0.00401
-
pH and temperature not specified in the publication Yersinia pestis 2-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]-1H-indene-1,3(2H)-dione
0.00444
-
pH and temperature not specified in the publication Yersinia pestis 5,7-bis[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2-methyltetrazolo[1,5-a]pyrimidin-2-ium
0.00448
-
pH and temperature not specified in the publication Yersinia pestis (4E)-2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzylidene)-1,3-oxazol-5(4H)-one
0.00461
-
pH and temperature not specified in the publication Yersinia pestis (2E)-2-[1-carbamothioyl-3-(4-nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]-1-(4-sulfophenyl)diazanide
0.00461
-
pH and temperature not specified in the publication Yersinia pestis 5-([1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indol-3-yl]methylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
0.00473
-
pH and temperature not specified in the publication Yersinia pestis 5-[4-(3,4-dihydroisoquinolin-2(1H)-yl)-3-nitrobenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
0.0081
-
pH and temperature not specified in the publication Yersinia pestis 5-([(E)-[2-(4-chlorophenyl)-5-oxo-1,3-oxazol-4(5H)-ylidene]methyl]amino)-2-hydroxybenzoic acid
0.00989
-
pH and temperature not specified in the publication Yersinia pestis 5-[4-[(2-chloro-6-fluorobenzyl)oxy]benzylidene]-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione