Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[a protein]-tyrosine phosphate + H2O | Mus musculus | - |
[a protein]-tyrosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[a protein]-tyrosine phosphate + H2O | - |
Mus musculus | [a protein]-tyrosine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Mus musculus |
PTP1B | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | PTP1B expression decreases progressively with adipocyte maturation | down |
General Information | Comment | Organism |
---|---|---|
malfunction | PTP1B knockdown accelerates adipocyte differentiation | Mus musculus |
physiological function | protein tyrosine phosphatase 1B is a negative regulator of systemic glucose and insulin homeostasis and inhibits adipocyte differentiation and mediates TNFalpha action in obesity | Mus musculus |