Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus BALB/c | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Mus musculus |
SHP-1 | - |
Mus musculus |
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of SHP-1 expression strongly augments the ability of regulatory T cells to suppress inflammation in a mouse model. Specific pharmacological inhibition of SHP-1 enzymatic activity via the cancer drug sodium stibogluconate potently augmented regulatory T cell suppressor activity both in vivo and ex vivo. SHP-1-deficient regulatory T cells are more efficient suppressors T-cell activation than wild-type regulatory T-cells | Mus musculus |
physiological function | the cytoplasmic tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1, SHP-1, acts as an endogenous brake and modifier of the suppressive ability of regulatory T cells, which are important for immune tolerance. Regulatory T cells prevent the activation of conventional T cells. Regulatory T cell -mediated suppression of Tcon activation occurs by multiple mechanisms and is regulated by SHP-1, overview | Mus musculus |