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Literature summary for 3.1.3.48 extracted from

  • Iype, T.; Sankarshanan, M.; Mauldin, I.S.; Mullins, D.W.; Lorenz, U.
    The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells (2010), J. Immunol., 185, 6115-6127.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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Mus musculus 5829
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus BALB/c
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-
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Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
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Mus musculus
SHP-1
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Mus musculus
tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1
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Mus musculus

General Information

General Information Comment Organism
malfunction loss of SHP-1 expression strongly augments the ability of regulatory T cells to suppress inflammation in a mouse model. Specific pharmacological inhibition of SHP-1 enzymatic activity via the cancer drug sodium stibogluconate potently augmented regulatory T cell suppressor activity both in vivo and ex vivo. SHP-1-deficient regulatory T cells are more efficient suppressors T-cell activation than wild-type regulatory T-cells Mus musculus
physiological function the cytoplasmic tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1, SHP-1, acts as an endogenous brake and modifier of the suppressive ability of regulatory T cells, which are important for immune tolerance. Regulatory T cells prevent the activation of conventional T cells. Regulatory T cell -mediated suppression of Tcon activation occurs by multiple mechanisms and is regulated by SHP-1, overview Mus musculus