Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S,6S,9R)-3,6-dimethyl-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | - |
Mycobacterium tuberculosis | |
(3S,6S,9R,12R)-3,6,9-trimethyl-12-[(R)-phenyl(phenylamino)methyl]-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone | - |
Mycobacterium tuberculosis | |
(3S,9R)-3-(4-hydroxybenzyl)-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | - |
Mycobacterium tuberculosis | |
(6R)-6-[(R)-phenyl(phenylamino)methyl]-1,4-diazepane-2,5-dione | - |
Mycobacterium tuberculosis | |
(9R)-9-[(R)-furan-2-yl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | - |
Mycobacterium tuberculosis | |
(9R)-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | - |
Mycobacterium tuberculosis | |
benzyl (3R,6S)-4,9-dioxo-3-[(R)-phenyl(phenylamino)methyl]-1,5-diazonane-6-carboxylate | - |
Mycobacterium tuberculosis | |
additional information | design of structure based cyclic peptide inhibitors, synthesis involves a crucial intramolecular transamidation via a ring opening reaction. All the compounds show moderate to good inhibitory activities against MPtpA in micromolar concentrations, enzyme docking study, overview | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate | mechanism of the dephosphorylation catalysed by MptpA | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
MPtpA | - |
Mycobacterium tuberculosis |
protein tyrosine phosphatase A | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
(3S,9R)-3-(4-hydroxybenzyl)-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | pH 7.5, 25°C | Mycobacterium tuberculosis | |
0.0363 | - |
benzyl (3R,6S)-4,9-dioxo-3-[(R)-phenyl(phenylamino)methyl]-1,5-diazonane-6-carboxylate | pH 7.5, 25°C | Mycobacterium tuberculosis | |
0.0855 | - |
(9R)-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | pH 7.5, 25°C | Mycobacterium tuberculosis | |
0.14 | - |
(6R)-6-[(R)-phenyl(phenylamino)methyl]-1,4-diazepane-2,5-dione | pH 7.5, 25°C | Mycobacterium tuberculosis | |
0.199 | - |
(3S,6S,9R,12R)-3,6,9-trimethyl-12-[(R)-phenyl(phenylamino)methyl]-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone | pH 7.5, 25°C | Mycobacterium tuberculosis | |
0.215 | - |
(9R)-9-[(R)-furan-2-yl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | pH 7.5, 25°C | Mycobacterium tuberculosis | |
0.22 | - |
(3S,6S,9R)-3,6-dimethyl-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione | pH 7.5, 25°C | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
metabolism | MPtpA is a signalling protein belonging to the tyrosine phosphatase superfamily, and is involved in phagocytosis and is active in virulent mycobacterial form | Mycobacterium tuberculosis |