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Literature summary for 3.1.3.48 extracted from

  • Tan, L.P.; Wu, H.; Yang, P.Y.; Kalesh, K.A.; Zhang, X.; Hu, M.; Srinivasan, R.; Yao, S.Q.
    High-throughput discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry (2009), Org. Lett., 11, 5102-5105.
    View publication on PubMed

Application

Application Comment Organism
drug development MptpB is a promising target for anti-tuberculosis drug development Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
F1S-6C-W11
-
Mycobacterium tuberculosis
H1-5C-W11
-
Mycobacterium tuberculosis
additional information PTP bidentate inhibitor library synthesis and screening, overview. The bidentate inhibitors have three components: 1. the warheads, alkyne-containing N-phenyloxamic acids that are cell-permeable, potent bioisosteric phosphotyrosine mimics, 2. a variety of different types of building blocks that act as the secondary-site binders, and 3. azide-containing linkers of different lengths joining the warhead and the building blocks, overview Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Synonyms

Synonyms Comment Organism
More the enzyme is a member of the PTP family Mycobacterium tuberculosis
MPtpB
-
Mycobacterium tuberculosis
protein tyrosine phosphatase B
-
Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00015
-
F1S-6C-W11
-
Mycobacterium tuberculosis
0.00017
-
H1-5C-W11
-
Mycobacterium tuberculosis