Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of PTP1B-/- mice, neuron-specific PTP1B-/- mice, and muscle specific-PTP1B-/- mice. Neuronal PTP1B-deficient mutant mice show inhibition of hypothalamic AMP-activated protein kinase, AMPK, and isoform-specific activation of AMPK in peripheral tissues, e.g. muscle and adipose tissue, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated AMP-activated protein kinase + H2O | Mus musculus | PTPB1 is involved in AMPK regulation through its phosphorylation in a tissue-specific manner, overview | AMP-activated protein kinase + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | - |
Mus musculus | - |
hypothalamus | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated AMP-activated protein kinase + H2O | PTPB1 is involved in AMPK regulation through its phosphorylation in a tissue-specific manner, overview | Mus musculus | AMP-activated protein kinase + phosphate | - |
? | |
phosphorylated AMP-activated protein kinase + H2O | phosphorylation of the AMPK alpha subunit at Thr172 | Mus musculus | AMP-activated protein kinase + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Mus musculus |
PTPB1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMP-activated protein kinase, AMPK, and isoform-specific activation of AMPK in peripheral tissues, overview | Mus musculus |