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Literature summary for 3.1.3.48 extracted from

  • Xue, B.; Pulinilkunnil, T.; Murano, I.; Bence, K.K.; He, H.; Minokoshi, Y.; Asakura, K.; Lee, A.; Haj, F.; Furukawa, N.; Catalano, K.J.; Delibegovic, M.; Balschi, J.A.; Cinti, S.; Neel, B.G.; Kahn, B.B.
    Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues (2009), Mol. Cell. Biol., 29, 4563-4573.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of PTP1B-/- mice, neuron-specific PTP1B-/- mice, and muscle specific-PTP1B-/- mice. Neuronal PTP1B-deficient mutant mice show inhibition of hypothalamic AMP-activated protein kinase, AMPK, and isoform-specific activation of AMPK in peripheral tissues, e.g. muscle and adipose tissue, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated AMP-activated protein kinase + H2O Mus musculus PTPB1 is involved in AMPK regulation through its phosphorylation in a tissue-specific manner, overview AMP-activated protein kinase + phosphate
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
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Mus musculus
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hypothalamus
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Mus musculus
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muscle
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Mus musculus
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neuron
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated AMP-activated protein kinase + H2O PTPB1 is involved in AMPK regulation through its phosphorylation in a tissue-specific manner, overview Mus musculus AMP-activated protein kinase + phosphate
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?
phosphorylated AMP-activated protein kinase + H2O phosphorylation of the AMPK alpha subunit at Thr172 Mus musculus AMP-activated protein kinase + phosphate
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?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
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Mus musculus
PTPB1
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Mus musculus

General Information

General Information Comment Organism
malfunction neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMP-activated protein kinase, AMPK, and isoform-specific activation of AMPK in peripheral tissues, overview Mus musculus