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Literature summary for 3.1.3.48 extracted from

  • Zhou, D.; Collins, C.A.; Wu, P.; Brown, E.J.
    Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase (2010), J. Leukoc. Biol., 87, 845-855.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C453S a catalytically inactive, dominant negative mutant of SHP-1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
female wild-type C57BL/6 mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein SHP-1 has a C-terminal tail containing at least two tyrosine phosphorylation sites Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic cell primary Mus musculus
-
macrophage bone-marrow-derived Mus musculus
-

Subunits

Subunits Comment Organism
More SHP-1 has two SH2 domains at its N terminus and a C-terminal tail containing at least two tyrosine phosphorylation sites Mus musculus

Synonyms

Synonyms Comment Organism
More SHP-1 is a member of SH2 domain-containing PTP subfamily Mus musculus
protein tyrosine phosphatase
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Mus musculus
SHP-1
-
Mus musculus

General Information

General Information Comment Organism
malfunction bone marrow-derived macrophages lacking significant SHP-1 activity display a profound defect in interleukin-12p40 synthesis in response to lipopolysaccharide, peptidoglycan, and synthetic Toll-like receptor ligands, while producing normal amounts of other proinflammatory cytokines, such as TNFalpha and interleukin-6 Mus musculus
physiological function SHP-1 plays critical roles in regulation of many receptor-mediated signaling cascades in the immune system, and it represents a mechanism for host regulation of a specific proinflammatory cytokine important in both innate and adaptive immunity. It is required for SHP-1 in interleukin-12/23 p40 production in response to Toll-like receptor stimulation in macrophages. SHP-1 regulation of interleukin-12p40 transcription requires both its catalytic activity and phosphotyrosine binding by its N-terminal SH2 domain and is mediated via repression of, and interaction with, phosphatidylinositol 3-kinase, without affecting c-Rel activation, overview Mus musculus