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Literature summary for 3.1.3.48 extracted from

  • Patrignani, C.; Lafont, D.T.; Muzio, V.; Greco, B.; Hooft van Huijsduijnen, R.; Zaratin, P.F.
    Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation (2010), J. Inflamm., 7, 16.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information construction of PTPH1 knockout mice, no immunological phenotype in primary T cells derived from PTPH1-KO mice, carrageenan induces a trend of slightly increased spontaneous pain sensitivity in PTPH1-KO mice compared to wild-type littermates, but no differences in cytokine release, induced pain perception and cellular infiltration, but LPS-induced TNFalpha, MCP-1, and IL10 release is significantly reduced in PTPH1-KO plasma compared to wild-type plasma, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte PTPH1 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated TCRzeta + H2O PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway Mus musculus TCRzeta + phosphate
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?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase H1
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Mus musculus
PTPH1
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Mus musculus

General Information

General Information Comment Organism
physiological function PTPH1 might play a role in the positive regulation of the LPS-induced cytokines release in vivo, in contrast to previous reports indicating PTPH1 as potential negative regulator of immune response Mus musculus