Protein Variants | Comment | Organism |
---|---|---|
C403S | a catalytically inactive mutant YopH | Yersinia sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl)methaneseleninic acid | inactivates the PTPs, e.g. YopH, by covalent modification, binds at the active site Cys403, kinetics, overview | Yersinia sp. | |
methyl 4-[(benzylseleninyl)methyl]-N-(tert-butoxycarbonyl)-L-phenylalaninate | - |
Yersinia sp. | |
methyl N-(tert-butoxycarbonyl)-4-(hydroxymethyl)-L-phenylalaninate | - |
Yersinia sp. | |
methyl N-(tert-butoxycarbonyl)-4-[(5R)-5-(methoxycarbonyl)-9,9-dimethyl-7-oxo-8-oxa-3-thia-2-selena-6-azadec-1-yl]-L-phenylalaninate | - |
Yersinia sp. |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33512 | - |
x * 33512, YopH PTP domain, residues 163-468, electrospray ion trap mass spectrometry | Yersinia sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yersinia sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in the YopH PTP catalytic mechanism, the active site Cys403 sits at the bottom of the pTyr-binding pocket, i.e., the active site, such that its Sgamma atom is poised 3 A from the phosphorus atom of the substrate ready for nucleophilic attack | Yersinia sp. | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 33512, YopH PTP domain, residues 163-468, electrospray ion trap mass spectrometry | Yersinia sp. |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Yersinia sp. |
YopH | - |
Yersinia sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Yersinia sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Yersinia sp. |