Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(difluoro[4-[(2,2,2-trifluoroethyl)carbamoyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
(difluoro[4-[(2-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
(difluoro[4-[(2-phenylethyl)carbamoyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
(difluoro[4-[(3-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
(difluoro[4-[(4-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
(difluoro[4-[(phenylamino)methyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
(difluoro[4-[2-oxo-2-(phenylamino)ethyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
(difluoro[4-[methyl(phenyl)carbamoyl]phenyl]methyl)phosphonic acid | - |
Mycobacterium tuberculosis | |
4-[difluoro(phosphono)methyl]benzoic acid | - |
Mycobacterium tuberculosis | |
additional information | inhibitor synthesis, structure-activity relationships, overview | Mycobacterium tuberculosis | |
[(1-benzyl-1H-indazol-5-yl)(difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[(2-benzyl-2H-indazol-5-yl)(difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[(4-bromophenyl)(difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[(4-[[3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[(4-[[4-bromo-3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | selectivity with different PTPs, overview | Mycobacterium tuberculosis | |
[(4-[[4-bromo-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[(4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[biphenyl-4-yl(difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro(4-nitrophenyl)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro(4-[[2-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro(4-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro(4-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro(4-[[4-fluoro-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[3-(phenylcarbamoyl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[4-(1,3-thiazol-2-ylcarbamoyl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[4-(methylcarbamoyl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[4-(phenoxymethyl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[4-(phenylcarbamoyl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[4-(phenylsulfamoyl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[difluoro[4-(propan-2-ylcarbamoyl)phenyl]methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-(1H-benzimidazol-2-ylcarbamoyl)phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-(benzoylamino)phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-(benzylcarbamoyl)phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-([[3,5-bis(trifluoromethyl)phenyl]carbamoyl]amino)phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-[(1-ethylpiperidin-4-yl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-[(2-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-[(2-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-[(3-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-[(3-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-[(4-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis | |
[[4-[(4-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | - |
Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WIA1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WIA1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Mycobacterium tuberculosis |
PtpA | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0014 | - |
[(4-[[4-bromo-3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0031 | - |
[[4-([[3,5-bis(trifluoromethyl)phenyl]carbamoyl]amino)phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0033 | - |
[(4-[[3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0049 | - |
[(4-[[4-bromo-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.006 | - |
[(4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0103 | - |
[[4-[(4-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0107 | - |
[difluoro(4-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0114 | - |
[difluoro(4-[[4-fluoro-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0168 | - |
[[4-[(4-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0182 | - |
[[4-[(3-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0185 | - |
[difluoro(4-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0227 | - |
(difluoro[4-[(4-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.024 | - |
[difluoro[4-(phenylcarbamoyl)phenyl]methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.033 | - |
[difluoro[4-(1,3-thiazol-2-ylcarbamoyl)phenyl]methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0349 | - |
[[4-[(3-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0418 | - |
(difluoro[4-[(3-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0431 | - |
[[4-(benzylcarbamoyl)phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0446 | - |
[[4-[(2-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0497 | - |
(difluoro[4-[(2,2,2-trifluoroethyl)carbamoyl]phenyl]methyl)phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0548 | - |
[difluoro(4-[[2-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0616 | - |
(difluoro[4-[(2-phenylethyl)carbamoyl]phenyl]methyl)phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0655 | - |
[[4-(benzoylamino)phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.068 | - |
[[4-[(2-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0754 | - |
[difluoro(4-nitrophenyl)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0844 | - |
[(2-benzyl-2H-indazol-5-yl)(difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.0923 | - |
[(4-bromophenyl)(difluoro)methyl]phosphonic acid | pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[difluoro[3-(phenylcarbamoyl)phenyl]methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
(difluoro[4-[2-oxo-2-(phenylamino)ethyl]phenyl]methyl)phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
4-[difluoro(phosphono)methyl]benzoic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[difluoro[4-(methylcarbamoyl)phenyl]methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[difluoro[4-(phenoxymethyl)phenyl]methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[(1-benzyl-1H-indazol-5-yl)(difluoro)methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[[4-[(1-ethylpiperidin-4-yl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
(difluoro[4-[(2-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
(difluoro[4-[methyl(phenyl)carbamoyl]phenyl]methyl)phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
(difluoro[4-[(phenylamino)methyl]phenyl]methyl)phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[difluoro[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[biphenyl-4-yl(difluoro)methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[difluoro[4-(propan-2-ylcarbamoyl)phenyl]methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis | |
0.1 | - |
[difluoro[4-(phenylsulfamoyl)phenyl]methyl]phosphonic acid | above, pH 6.2, 37°C | Mycobacterium tuberculosis |