Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.48 extracted from

  • McAlees, J.W.; Sanders, V.M.
    Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes (2009), Mol. Cell. Biol., 29, 675-686.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.48

Inhibitors

Inhibitors Comment Organism Structure
additional information beta2AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Mus musculus
-
CH12.LX cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HePTP plays a role in regulating the level of p38 MAPK phosphorylation in B-lymphocytes, HePTP can be phosphorylated by PKA, which inactivates the phosphatase and causes it to release p38 MAPK into the cytoplasm Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
hematopoietic protein tyrosine phosphatase
-
 Mus musculus
HEPTP
-
 Mus musculus