Application | Comment | Organism |
---|---|---|
medicine | PTP-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes | Macaca mulatta |
medicine | PTP-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes | Macaca fascicularis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ISIS 113715 | PTP-1B antisense oligonucleotide ISIS 113715 dose-dependently inhibits PTP-1B mRNA and protein expression, although ISIS 113715 reduces PTP-1B protein levels by greater than 90%, no effects are observed on protein levels of TC-PTPase | Macaca fascicularis | |
ISIS 113715 | PTP-1B antisense oligonucleotide ISIS 113715 administration reduces PTP-1B mRNA expression in both liver and adipose tissue by 40-50% but does not affect muscle PTP-1B expression | Macaca mulatta |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Macaca fascicularis | - |
- |
- |
Macaca mulatta | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Macaca mulatta | - |
adipose tissue | - |
Macaca fascicularis | - |
hepatocyte | - |
Macaca fascicularis | - |
liver | - |
Macaca mulatta | - |
liver | - |
Macaca fascicularis | - |
muscle | - |
Macaca mulatta | - |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase-1B | - |
Macaca mulatta |
protein tyrosine phosphatase-1B | - |
Macaca fascicularis |
PTP-1B | - |
Macaca mulatta |
PTP-1B | - |
Macaca fascicularis |
TC-PTPase ยด | - |
Macaca fascicularis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
IC50 less than 0.00001 mM | Macaca mulatta | ISIS 113715 | |
0.00001 | - |
IC50 less than 0.00001 mM | Macaca fascicularis | ISIS 113715 |