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Literature summary for 3.1.3.48 extracted from

  • Swarbrick, M.M.; Havel, P.J.; Levin, A.A.; Bremer, A.A.; Stanhope, K.L.; Butler, M.; Booten, S.L.; Graham, J.L.; McKay, R.A.; Murray, S.F.; Watts, L.M.; Monia, B.P.; Bhanot, S.
    Inhibition of protein tyrosine phosphatase-1B (PTP-1B) with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys (2009), Endocrinology, 150, 1670-1679.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine PTP-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes Macaca mulatta
medicine PTP-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes Macaca fascicularis

Inhibitors

Inhibitors Comment Organism Structure
ISIS 113715 PTP-1B antisense oligonucleotide ISIS 113715 dose-dependently inhibits PTP-1B mRNA and protein expression, although ISIS 113715 reduces PTP-1B protein levels by greater than 90%, no effects are observed on protein levels of TC-PTPase Macaca fascicularis
ISIS 113715 PTP-1B antisense oligonucleotide ISIS 113715 administration reduces PTP-1B mRNA expression in both liver and adipose tissue by 40-50% but does not affect muscle PTP-1B expression Macaca mulatta

Organism

Organism UniProt Comment Textmining
Macaca fascicularis
-
-
-
Macaca mulatta
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Macaca mulatta
-
adipose tissue
-
Macaca fascicularis
-
hepatocyte
-
Macaca fascicularis
-
liver
-
Macaca mulatta
-
liver
-
Macaca fascicularis
-
muscle
-
Macaca mulatta
-

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase-1B
-
Macaca mulatta
protein tyrosine phosphatase-1B
-
Macaca fascicularis
PTP-1B
-
Macaca mulatta
PTP-1B
-
Macaca fascicularis
TC-PTPase ยด
-
Macaca fascicularis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
IC50 less than 0.00001 mM Macaca mulatta ISIS 113715
0.00001
-
IC50 less than 0.00001 mM Macaca fascicularis ISIS 113715