Cloned (Comment) | Organism |
---|---|
expressed in HUVEC cells, overexpression of PTP1B stabilizes VE-cadherin-mediated cell-cell adhesions by reducing VE-cadherin tyrosine phosphorylation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C215S | the mutant is catalytically inactive | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Mus musculus | - |
hindlimb | PTP1B protein is robustly increased in the ischemic hindlimb | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | phospho-p38 mitogen-activated protein kinase and Akt are not dephosphorylated | Mus musculus | ? | - |
? | |
phosphorylated ERK + H2O | dephosphorylation at Tyr-1175 | Mus musculus | ERK + phosphate | - |
? | |
phosphorylated phospholipase Cgamma + H2O | dephosphorylation occurs at Tyr-783 | Mus musculus | phospholipase Cgamma + phosphate | - |
? | |
phosphorylated vascular endothelial growth factor receptor 2 + H2O | dephosphorylation occurs at Tyr-1175, PTP1B binds to vascular endothelial growth factor receptor 2 cytoplasmic domain and directly dephosphorylates activated vascular endothelial growth factor receptor 2 immunoprecipitates | Mus musculus | vascular endothelial growth factor receptor 2 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Mus musculus |
PTP1B | - |
Mus musculus |