Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.48 extracted from

  • Pendyala, P.R.; Ayong, L.; Eatrides, J.; Schreiber, M.; Pham, C.; Chakrabarti, R.; Fidock, D.A.; Allen, C.M.; Chakrabarti, D.
    Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum (2008), Mol. Biochem. Parasitol., 158, 1-10.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) codon plus cells as GST fusion protein Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
sodium orthovanadate shows dose-dependent inhibition of PRL activity Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
3-O-methylfluorescein phosphate in 50 mM sodium acetate (pH 5.5), 80 mM NaCl, 10 mM dithiothreitol, and 20% glycerol, at 22°C Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Plasmodium falciparum 5783
-
vacuole
-
Plasmodium falciparum 5773
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
SDS-PAGE Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
GST-bind affinity chromatography Plasmodium falciparum

Source Tissue

Source Tissue Comment Organism Textmining
schizont
-
Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-O-methylfluorescein phosphate + H2O
-
Plasmodium falciparum 3-O-methylfluorescein + phosphate
-
?

Synonyms

Synonyms Comment Organism
PRL
-
Plasmodium falciparum
PRL-related protein tyrosine phosphatase
-
Plasmodium falciparum
protein of regenerating liver-related protein tyrosine phosphatase
-
Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.24
-
3-O-methylfluorescein phosphate in 50 mM sodium acetate (pH 5.5), 80 mM NaCl, 10 mM dithiothreitol, and 20% glycerol, at 22°C Plasmodium falciparum