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Literature summary for 3.1.3.48 extracted from

  • Haj, F.G.; Zabolotny, J.M.; Kim, Y.B.; Kahn, B.B.; Neel, B.G.
    Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice (2005), J. Biol. Chem., 280, 15038-15046.
    View publication on PubMed

Application

Application Comment Organism
medicine homozygous enzyme-deficient animal, hyperresponsive to insulin and leptin and resistant to diet-induced obesity. Liver-specific re-expression of PTP1B leads to marked attenuation of their enhanced insulin sensitivity in correlation with decreased insulin-stimulated tyrosyl phosphorylation of the insulin receptor and insulin receptor substrate 2-associated phosphatidylinositide 3-kinase activity. Preferential dephosphorylation of Y1162/1163 of insulin receptor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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homozygous PTP1B-deficient animal, hyperresponsive to insulin and leptin and resistant to diet-induced obesity
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated insulin receptor + H2O
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Mus musculus insulin receptor + phosphate preferential dephosphorylation of Y1162/1163 of insulin receptor ?