Application | Comment | Organism |
---|---|---|
medicine | homozygous enzyme-deficient animal, hyperresponsive to insulin and leptin and resistant to diet-induced obesity. Liver-specific re-expression of PTP1B leads to marked attenuation of their enhanced insulin sensitivity in correlation with decreased insulin-stimulated tyrosyl phosphorylation of the insulin receptor and insulin receptor substrate 2-associated phosphatidylinositide 3-kinase activity. Preferential dephosphorylation of Y1162/1163 of insulin receptor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
homozygous PTP1B-deficient animal, hyperresponsive to insulin and leptin and resistant to diet-induced obesity | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated insulin receptor + H2O | - |
Mus musculus | insulin receptor + phosphate | preferential dephosphorylation of Y1162/1163 of insulin receptor | ? |