Cloned (Comment) | Organism |
---|---|
- |
Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-ethylmaleimide | both isozymes, 50% inhibition at 7 mM | Staphylococcus aureus | |
sodium orthovanadate | both isozymes, 50% inhibition at 3 mM | Staphylococcus aureus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.2 | - |
4-nitrophenyl phosphate | pH 6.2, 37°C, PtpA | Staphylococcus aureus | |
1.5 | - |
4-nitrophenyl phosphate | pH 6.2, 37°C, PtpB | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
LMW-PTP, isozymes PtpA and PtpB | - |
Purification (Comment) | Organism |
---|---|
recombinant protein expressed in Escherichia coli | Staphylococcus aureus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.4 | - |
pH 6.2, 37°C, PtpB | Staphylococcus aureus |
33.6 | - |
pH 6.2, 37°C, PtpA | Staphylococcus aureus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PtpA, PtpB act specifically on phosphotyrosine residues | Staphylococcus aureus | ? | - |
? | |
p-nitrophenyl phosphate + H2O | - |
Staphylococcus aureus | p-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PtpA | - |
Staphylococcus aureus |
PtpB | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
PtpA, PtpB | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
PtpA | Staphylococcus aureus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.7 | 6.5 | PtpB | Staphylococcus aureus |