Application | Comment | Organism |
---|---|---|
medicine | pharmacological disruption of the PFKFB4 kinase domain may have clinical utility for the treatment of human cancers | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-D-fructose 2,6-bisphosphate + H2O | Homo sapiens | - |
D-fructose 6-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16877 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung adenocarcinoma cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-D-fructose 2,6-bisphosphate + H2O | - |
Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | - |
Homo sapiens |
PFKFB4 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme isoform PFKFB4 is about 3fold overexpressed in lung adenocarcinoma compared to normal lung tissue. PFKFB4 mRNA and protein expression are also increased by hypoxia | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of isoform PFKFB4 reduces tumor growth, glucose uptake and beta-D-fructose 2,6-bisphosphate and increases apoptosis | Homo sapiens |
physiological function | fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 is required for the glycolytic response to hypoxia and tumor growth | Homo sapiens |