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Literature summary for 3.1.3.46 extracted from

  • Novellasdemunt, L.; Tato, I.; Navarro-Sabate, A.; Ruiz-Meana, M.; Mendez-Lucas, A.; Perales, J.C.; Garcia-Dorado, D.; Ventura, F.; Bartrons, R.; Rosa, J.L.
    Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids (2013), J. Biol. Chem., 288, 10640-10651.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.46

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O Rattus norvegicus
-
 D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens
-
 D-fructose 6-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60825
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Akt phosphorylates the enzyme at Ser-483 Rattus norvegicus
phosphoprotein Akt phosphorylates the enzyme at Ser-483 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
heart
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Rattus norvegicus
heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Homo sapiens
PFKFB2
-
 Rattus norvegicus
PFKFB2
-
 Homo sapiens