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Literature summary for 3.1.3.46 extracted from

  • Moon, J.S.; Jin, W.J.; Kwak, J.H.; Kim, H.J.; Yun, M.J.; Kim, J.W.; Park, S.W.; Kim, K.S.
    Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells (2011), Biochem. J., 433, 225-233.
    View publication on PubMed
Search for more literature for 3.1.3.46

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PI3K/Akt signalling is involved in the phosphorylation of Ser466 and Ser483 of PFKFB2 in LNCaP cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart cardiac isoform Homo sapiens
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LNCaP cell
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 Homo sapiens
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prostate cancer cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
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 Homo sapiens
PFKFB2
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, up-regulation of PFKFB2 expression in LNCaP cells is mediated by the direct binding of ligand-activated androgen receptor to the PFKFB2 promoter. Expression of PFKFB2 gene is increased 3.0fold by treatment with methyltrienolone, i.e. R1881, a synthetic androgen up

General Information

General Information Comment Organism
additional information androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, up-regulation of PFKFB2 expression is mediated by the direct binding of ligand-activated androgen receptor to the PFKFB2 promoter Homo sapiens
physiological function PFKFB2 has a critical role in glucose uptake and glucose-dependent lipid synthesis. Induction of de novo lipid synthesis by androgen requires the transcriptional up-regulation of HK2 and PFKFB2, and phosphorylation of PFKFB2 generated by the PI3K/Akt signalling pathway to supply the source for lipogenesis from glucose in prostate cancer cells Homo sapiens