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Literature summary for 3.1.3.46 extracted from

  • Arden, C.; Hampson, L.J.; Huang, G.C.; Shaw, J.A.; Aldibbiat, A.; Holliman, G.; Manas, D.; Khan, S.; Lange, A.J.; Agius, L.
    A role for PFK-2/FBPase-2 as distinct from fructose 2,6-bisphosphate in regulation of insulin secretion in pancreatic beta-cells (2007), Biochem. J., 411, 41-51.
    View publication on PubMed
Search for more literature for 3.1.3.46

Application

Application Comment Organism
molecular biology overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion Mus musculus
molecular biology overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression in hepatocytes by incubation for 2h with increasing titres of adenoviral vectors Rattus norvegicus
expression in MIN-6 cell by incubation for 2h with increasing titres of adenoviral vectors Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?
additional information Rattus norvegicus the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?
additional information Mus musculus C57/BL6 the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?
additional information Rattus norvegicus Wistar the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 C57/BL6
-
Mus musculus C57/BL6
-
 C57/BL6
-
Rattus norvegicus
-
 Wistar
-
Rattus norvegicus Wistar
-
 Wistar
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
INS-1 cell
-
 Rattus norvegicus
-
MIN-6 cell
-
 Mus musculus
-
additional information PFKFB2 and PFKFB3 mRNA is expressed in human islet cells Homo sapiens
-
pancreatic islet
-
 Mus musculus
-
pancreatic islet
-
 Homo sapiens
-
pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O
-
 Mus musculus D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O
-
 Mus musculus C57/BL6 D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus Wistar D-fructose 6-phosphate + phosphate
-
 ?
additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Mus musculus ?
-
 ?
additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Rattus norvegicus ?
-
 ?
additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Mus musculus C57/BL6 ?
-
 ?
additional information the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting Rattus norvegicus Wistar ?
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Mus musculus
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Homo sapiens
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Rattus norvegicus
FBPase-2
-
 Mus musculus
FBPase-2
-
 Homo sapiens
FBPase-2
-
 Rattus norvegicus
PFKFB1
-
 Mus musculus
PFKFB1
-
 Homo sapiens
PFKFB1
-
 Rattus norvegicus
PFKFB2
-
 Mus musculus
PFKFB2
-
 Homo sapiens
PFKFB2
-
 Rattus norvegicus
PFKFB3
-
 Mus musculus
PFKFB3
-
 Homo sapiens
PFKFB3
-
 Rattus norvegicus